Naruto is the first to engage Isshiki. Meanwhile, Sasuke creates a plan to pull Isshiki from the village. The immediate danger to the foliage village is now averted.
Momoshiki using Boruto as the vessel and Isshiki in his weakened form, this struggle won’t end well for Isshiki. Consequently, Isshiki will prevent Boruto and reach Konoha again.
His top priority is to get Kawaki. In addition to Amado, Kawaki is maintained in an underground place that is tough to find for most people.
To avoid that outcome, Naruto and Sasuke will fight against Isshiki in the next chapter. Even though they are overpowered, they will attempt to subdue Isshiki.
Jigen wasn’t a proper boat and Isshiki is in a weakened state. Isshiki could satisfy the same ending as Kaguya but he’s strong enough to get Kawaki back and extend his life.
The Karma will require a while to extract into Kawaki’s body. Till then they will require a solution from the Karma. We will need Amado for that. In the latest chapter, readers found that Isshiki will be a bigger issue than Jigen.
Since Sasuke and Naruto were defeated badly in the fight, they’ll need as much help as they can get to defeat Isshiki.